Scott A. Leddon, PhD

As the Senior Research Associate in the Fowell Laboratory, Scott functions as the lab’s go-to for experimental planning, technical implementation, and data analysis.

His primary research focus is to understand how temporal and microanatomical cues within the germinal center impact the ability of T cells to effectively help B cells. Spatiotemporal cues controlling the germinal center reaction represent an attractive immunomodulatory target to either enhance protective antibody responses to pathogens or to diminish antibody-mediated autoimmunity.

Scott completed his Ph.D. at the laboratory of Andrea Sant where he worked on understanding the antigen-specificity of T follicular helper cells after vaccination. He then worked as a postdoctoral fellow in the laboratory of Jim Miller where he identified a dimerization domain within CD28, before joining the laboratory of Deborah Fowell in 2017. As a postdoctoral associate in the Fowell lab, Scott identified a critical role for alpha-v integrin expression by CD4 T cells for the generation of long-lived plasma cells.

In October 2020, Scott moved with Deborah Fowell to the Department of Microbiology & Immunology in the College for Veterinary Medicine at Cornell University in Ithaca, NY.